The Centre has issued an advisory on the rational use of cough syrups in the pediatric population after the tragic death of 12 children in MP and Rajasthan. Laboratory analyses have confirmed the presence of diethylene glycol (DEG), a toxic industrial chemical, in the syrups, which is believed to have caused the fatal kidney injuries. The MP government has imposed an immediate ban on the sale of Coldrif and Nextro-DS syrups along with prohibiting the sale of other products manufactured by the same company. MP Chief Minister Dr. Mohan Yadav announced the ban on ‘X’, formerly Twitter.The Union Health Ministry has advised all states and union territories that cough and cold medications should not be prescribed or dispensed to children below two years. This all is followed after the victims initially presented with mild symptoms like fever and cold, but their conditions rapidly deteriorated and lead to renal complications.
Banned cough Syrups: Coldrif and Nextro-DS
- Coldrif is a pediatric cough syrup manufactured by Sresan Pharmaceuticals, based in Tamil Nadu. Laboratory tests have confirmed that Coldrif syrup contains diethylene glycol (DEG) levels exceeding permissible limits.
- Nextro-DS is another pediatric cough syrup produced by the same manufacturer. Initial reports indicate that some children who consumed Nextro-DS also suffered from kidney failure, however, lab analyses have not yet confirmed the presence of DEG in Nextro-DS, investigations are ongoing.
Diethylene glycol and its link to kidney failure
Diethylene glycol is a toxic industrial chemical. It is commonly used in antifreeze and other industrial applications. DEG is not safe for human consumption. When ingested, DEG is metabolized in the body into harmful compounds that can cause acute kidney injury, metabolic acidosis, and multi-organ failure. In children, especially, even a small amount can prove to be fatal.Parents should be extremely cautious when giving medications to children. Cough and cold syrups should never be administered without consulting a qualified pediatrician.
- Avoid self-medication: Do not give children over-the-counter cough and cold syrups without consulting a pediatrician, especially children under two years of age.
- Seek professional guidance: For symptoms like cough, cold, or mild fever, consult a qualified pediatrician before administering any medicine.
- Check labels carefully: Verify the brand, manufacturer, batch number, and expiry date before using any syrup. Avoid locally repackaged or unverified products.
- Monitor symptoms: Watch for lethargy, vomiting, reduced urine output, or unusual fatigue after any medication. Seek immediate medical attention if these occur.
- Use only safe sources: Buy medicines from reliable pharmacies. Avoid private shops or unknown suppliers.
- Report adverse effects: If your child develops any unusual reaction, report it immediately to the doctor and local health authorities.
