Liver disease claims about two million lives annually, which is 4% of all deaths (1 out of every 25 deaths worldwide), according to a 2023 study. Among this, approximately two-thirds of all liver-related deaths occur in men. Cirrhosis and hepatocellular carcinoma are the major causes of death, of which the former is linked to viral hepatitis, alcohol, and non-alcoholic fatty liver disease. Early detection is crucial for identifying liver diseases. Dr. Saurabh Sethi, a leading California-based gastroenterologist, has raised awareness about a few overlooked signs, which start with your skin. “You can check these at home,” the liver specialist said. Here are four signs of liver disease that appear on the skin. Watch out for these signs. Yellowing of the skin and eyes/ Jaundice

Jaundice is the first and most evident sign of liver disease. You may notice yellowing of the skin and eyes. “This is a classic sign of liver disease,” the doctor said in a video shared on Instagram. Dr. Sethi explained that the yellowing of the skin and eyes occurs due to elevated levels of bilirubin. It is a yellow pigment produced during red blood cell breakdown. The liver is responsible for the processing of bilirubin; however, when it dysfunctions, this pigment builds up in the system, leaving the skin and eyes yellow. If you notice this sign, it is important to seek immediate medical attention.Spider angiomas
Another crucial sign of liver dysfunction is the appearance of spider angiomas. Dr. Sethi explains that these are small, dilated blood vessels that resemble spider webs, which typically appear on the face, neck, or chest. The doctor noted that these spider webs are formed due to the increased levels of estrogen, which can result from liver dysfunction. The liver is responsible for metabolizing hormones. But when it does not function properly, these hormones, including estrogen, can build up.Palmar erythema
One sign that people tend to overlook is redness and inflammation of the palms. This condition is called palmar erythema. Dr. Sethi added that this symptom is often accompanied by swelling. “ This is due to increased blood flow and estrogen levels, which can be a sign of liver dysfunction,” Dr. Sethi said. One may find their palms look flushed and red, and may also experience warmth. This symptom is often overlooked or mistaken for physical strain or other skin issues.
Itching
Itching of the skin is another warning sign that your liver is not functioning properly. This symptom may worsen at night. Dr. Sethi explained that itching happens due to the buildup of bile salts in the skin. This itch is different from dry skin or allergies. It often lingers longer and could significantly affect your life. If the itching is accompanied by other symptoms, it’s a warning sign. Disclaimer: This information is intended for general knowledge only and should not be used as a substitute for professional medical advice, diagnosis, or treatment.