A landmark study found that higher LDL levels were strongly associated with incident PAD, even after adjusting for smoking and hypertension. A major meta-analysis in Lancet also confirmed that every 1 mmol/L reduction in LDL reduces the risk of major vascular disease, including PAD, by roughly 20–25%.
Why high LDL leads to PAD:
• LDL particles infiltrate artery walls and form plaque
• Triggers inflammation and foam-cell formation
• Accelerates narrowing in leg arteries
Managing LDL starts with a heart-healthy diet rich in vegetables, fruits, whole grains, and healthy fats, while limiting saturated and trans fats. Regular exercise and maintaining a healthy weight help lower cholesterol naturally.
